Assay Detail
Binding
CHEMBL890060
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human SERT
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Dual serotonin transporter/histamine H3 ligands: Optimization of the H3 pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 8.17 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL394787 | — | — | 1 | 8.74 |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 8.70 |
| CHEMBL396459 | — | — | 1 | 8.70 |
| CHEMBL233054 | — | — | 1 | 8.54 |
| CHEMBL396703 | — | — | 1 | 8.54 |
| CHEMBL233471 | — | — | 1 | 8.49 |
| CHEMBL396945 | — | — | 1 | 8.47 |
| CHEMBL394800 | — | — | 1 | 8.42 |
| CHEMBL242820 | — | — | 1 | 8.40 |
| CHEMBL427845 | — | — | 1 | 8.40 |
| CHEMBL234526 | — | — | 1 | 8.32 |
| CHEMBL394861 | — | — | 1 | 8.29 |
| CHEMBL396981 | — | — | 1 | 8.28 |
| CHEMBL394801 | — | — | 1 | 8.28 |
| CHEMBL395096 | — | — | 1 | 8.19 |
| CHEMBL233053 | — | — | 1 | 8.19 |
| CHEMBL242817 | — | — | 1 | 8.14 |
| CHEMBL234732 | — | — | 1 | 8.14 |
| CHEMBL395022 | — | — | 1 | 8.10 |
| CHEMBL233470 | — | — | 1 | 8.09 |
| CHEMBL232218 | — | — | 1 | 8.06 |
| CHEMBL232661 | — | — | 1 | 8.01 |
| CHEMBL234525 | — | — | 1 | 7.92 |
| CHEMBL233681 | — | — | 1 | 7.85 |
| CHEMBL232621 | — | — | 1 | 7.82 |
| CHEMBL245130 | — | — | 1 | 7.75 |
| CHEMBL429440 | — | — | 1 | 7.72 |
| CHEMBL232660 | — | — | 1 | 7.71 |
| CHEMBL232010 | — | — | 1 | 7.48 |
| CHEMBL232620 | — | — | 1 | 7.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL394787 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL41 | FLUOXETINE | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL396459 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL233054 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL396703 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL233471 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL396945 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL394800 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL242820 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL427845 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL234526 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL394861 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL396981 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL394801 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL395096 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL233053 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL242817 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL234732 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL395022 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL233470 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL232218 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL232661 | — | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL234525 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL233681 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL232621 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL245130 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL429440 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL232660 | — | Ki | = | 19.3 | nM | 7.71 |
| CHEMBL232010 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL232620 | — | Ki | = | 42.0 | nM | 7.38 |