Assay Detail
Functional
CHEMBL890206
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human mu opioid receptor expressed in CHO cells by [35S]GTP-gamma-S binding assay
11
Total Activities
11
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthetic studies of neoclerodane diterpenes from Salvia divinorum: preparation and opioid receptor activity of salvinicin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.84 | 6.37 |
| Ke | 4 | - | - |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL210564 | — | — | 1 | 6.37 |
| CHEMBL226784 | — | — | 1 | 5.86 |
| CHEMBL226731 | — | — | 1 | 5.82 |
| CHEMBL226732 | — | — | 1 | 5.63 |
| CHEMBL434746 | — | — | 1 | 5.53 |
| CHEMBL445332 | SALVINORIN A | 1.0 | 1 | - |
| CHEMBL390935 | — | — | 1 | - |
| CHEMBL427280 | — | — | 1 | - |
| CHEMBL226785 | — | — | 1 | - |
| CHEMBL226943 | SALVIDIVIN A | — | 1 | - |
| CHEMBL440765 | U-69593 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL210564 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL226784 | — | Ki | = | 1370.0 | nM | 5.86 |
| CHEMBL226731 | — | Ki | = | 1530.0 | nM | 5.82 |
| CHEMBL226732 | — | Ki | = | 2320.0 | nM | 5.63 |
| CHEMBL434746 | — | Ki | = | 2930.0 | nM | 5.53 |
| CHEMBL445332 | SALVINORIN A | Ke | - | — | - | |
| CHEMBL390935 | — | Ke | - | — | - | |
| CHEMBL427280 | — | Activity | - | — | - | |
| CHEMBL226785 | — | Activity | - | — | - | |
| CHEMBL226943 | SALVIDIVIN A | Ke | = | 760.0 | nM | - |
| CHEMBL440765 | U-69593 | Ke | - | — | - |