Assay Detail
Binding
CHEMBL890491
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Displacement of [3H]PDBu from mouse PKCdelta C1b Q27E mutant expressed in Escherichia coli
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Conformationally constrained analogues of diacylglycerol (DAG). 28. DAG-dioxolanones reveal a new additional interaction site in the C1b domain of PKC delta.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.68 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27768 | — | — | 1 | 8.21 |
| CHEMBL96766 | — | — | 1 | 7.35 |
| CHEMBL231617 | — | — | 1 | 7.28 |
| CHEMBL230048 | — | — | 1 | 7.13 |
| CHEMBL397713 | — | — | 1 | 5.76 |
| CHEMBL442232 | — | — | 1 | 5.60 |
| CHEMBL231141 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27768 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL96766 | — | Ki | = | 44.8 | nM | 7.35 |
| CHEMBL231617 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL230048 | — | Ki | = | 73.72 | nM | 7.13 |
| CHEMBL397713 | — | Ki | = | 1720.0 | nM | 5.76 |
| CHEMBL442232 | — | Ki | = | 2510.0 | nM | 5.60 |
| CHEMBL231141 | — | Ki | = | 3460.0 | nM | 5.46 |