Compound Detail
CHEMBL442232
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Basic Information
| ChEMBL ID | CHEMBL442232 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FNAVULFGMYGNQE-RQZCQDPDSA-N |
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
384.5
MW (Da)
3.82
ALogP
6
HBA
1
HBD
82.1
PSA (Ų)
0.48
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 4 meas. best 9.09
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein kinase C delta type CHEMBL2560 | Ki | 9.09 | 7.215 | 0.8 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein kinase C delta type | Ki | = | 0.82 | nM | 9.09 | Displacement of [3H]PDBu from mouse wild type C1b domain of PKCdelta expressed i... | 17591763 |
| Protein kinase C delta type | Ki | = | 4.31 | nM | 8.37 | Binding affinity to mouse wild-type PKCdelta C1a expressed in Escherichia coli | 17591763 |
| Protein kinase C delta type | Ki | = | 1567.0 | nM | 5.8 | Binding affinity to mouse PKC delta C1a Q27E mutant expressed in Escherichia col... | 17591763 |
| Protein kinase C delta type | Ki | = | 2510.0 | nM | 5.6 | Displacement of [3H]PDBu from mouse PKCdelta C1b Q27E mutant expressed in Escher... | 17591763 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17591763 | 10.1021/jm0702579 | Protein kinase C delta type | 9 |
Data from ChEMBL 36 via Core Engine