Assay Detail
Binding
CHEMBL890494
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to mouse wild-type PKCdelta C1a expressed in Escherichia coli
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Conformationally constrained analogues of diacylglycerol (DAG). 28. DAG-dioxolanones reveal a new additional interaction site in the C1b domain of PKC delta.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.65 | 8.92 |
| Kd | 1 | 8.69 | 8.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96766 | — | — | 1 | 8.92 |
| CHEMBL27768 | — | — | 1 | 8.69 |
| CHEMBL442232 | — | — | 1 | 8.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96766 | — | Ki | = | 1.21 | nM | 8.92 |
| CHEMBL27768 | — | Kd | = | 2.04 | nM | 8.69 |
| CHEMBL442232 | — | Ki | = | 4.31 | nM | 8.37 |