Assay Detail
Binding
CHEMBL890738
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]paroxetine from SERT in Sprague-Dawley rat brain
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis, monoamine transporter binding, properties, and functional monoamine uptake activity of 3beta-[4-methylphenyl and 4-chlorophenyl]-2 beta-[5-(substituted phenyl)thiazol-2-yl]tropanes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 6.08 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376113 | — | — | 1 | 6.72 |
| CHEMBL227231 | — | — | 1 | 6.55 |
| CHEMBL388760 | — | — | 1 | 6.52 |
| CHEMBL436132 | — | — | 1 | 6.51 |
| CHEMBL390743 | — | — | 1 | 6.43 |
| CHEMBL388612 | — | — | 1 | 6.42 |
| CHEMBL227233 | — | — | 1 | 6.10 |
| CHEMBL388759 | — | — | 1 | 6.08 |
| CHEMBL227180 | — | — | 1 | 6.04 |
| CHEMBL227232 | — | — | 1 | 6.01 |
| CHEMBL229381 | — | — | 1 | 5.96 |
| CHEMBL388832 | — | — | 1 | 5.82 |
| CHEMBL229436 | — | — | 1 | 5.77 |
| CHEMBL390742 | TROPARIL | — | 1 | 5.72 |
| CHEMBL229699 | — | — | 1 | 5.65 |
| CHEMBL226984 | — | — | 1 | 5.00 |
| CHEMBL227179 | — | — | 1 | - |
| CHEMBL226933 | — | — | 1 | - |
| CHEMBL2113279 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376113 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL227231 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL388760 | — | Ki | = | 301.0 | nM | 6.52 |
| CHEMBL436132 | — | Ki | = | 312.0 | nM | 6.51 |
| CHEMBL390743 | — | Ki | = | 371.0 | nM | 6.43 |
| CHEMBL388612 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL227233 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL388759 | — | Ki | = | 840.0 | nM | 6.08 |
| CHEMBL227180 | — | Ki | = | 903.0 | nM | 6.04 |
| CHEMBL227232 | — | Ki | = | 980.0 | nM | 6.01 |
| CHEMBL229381 | — | Ki | = | 1110.0 | nM | 5.96 |
| CHEMBL388832 | — | Ki | = | 1510.0 | nM | 5.82 |
| CHEMBL229436 | — | Ki | = | 1690.0 | nM | 5.77 |
| CHEMBL390742 | TROPARIL | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL229699 | — | Ki | = | 2240.0 | nM | 5.65 |
| CHEMBL226984 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL227179 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL226933 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL2113279 | — | Ki | > | 2000.0 | nM | - |