Assay Detail
Functional
CHEMBL891327
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Inhibition of IL1-beta production in THP1 cells
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of unsaturated caprolactams as interleukin-1beta converting enzyme (ICE) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.48 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL394351 | — | — | 1 | 7.44 |
| CHEMBL242727 | — | — | 1 | 7.15 |
| CHEMBL268772 | — | — | 1 | 7.02 |
| CHEMBL242509 | — | — | 1 | 7.00 |
| CHEMBL242938 | — | — | 1 | 6.82 |
| CHEMBL242298 | — | — | 1 | 6.74 |
| CHEMBL396534 | — | — | 1 | 6.73 |
| CHEMBL411758 | — | — | 1 | 6.63 |
| CHEMBL411178 | — | — | 1 | 6.61 |
| CHEMBL411759 | — | — | 1 | 6.49 |
| CHEMBL242726 | — | — | 1 | 6.42 |
| CHEMBL397184 | — | — | 1 | 6.33 |
| CHEMBL442714 | — | — | 1 | 6.26 |
| CHEMBL397990 | — | — | 1 | 6.26 |
| CHEMBL396535 | — | — | 1 | 6.23 |
| CHEMBL242510 | — | — | 1 | 6.15 |
| CHEMBL242937 | — | — | 1 | 6.06 |
| CHEMBL242511 | — | — | 1 | 5.97 |
| CHEMBL429646 | — | — | 1 | 5.91 |
| CHEMBL244229 | — | — | 1 | 5.89 |
| CHEMBL243823 | — | — | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL394351 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL242727 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL268772 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL242509 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL242938 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL242298 | — | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL396534 | — | IC50 | = | 188.0 | nM | 6.73 |
| CHEMBL411758 | — | IC50 | = | 232.0 | nM | 6.63 |
| CHEMBL411178 | — | IC50 | = | 243.0 | nM | 6.61 |
| CHEMBL411759 | — | IC50 | = | 326.0 | nM | 6.49 |
| CHEMBL242726 | — | IC50 | = | 383.0 | nM | 6.42 |
| CHEMBL397184 | — | IC50 | = | 466.0 | nM | 6.33 |
| CHEMBL442714 | — | IC50 | = | 543.0 | nM | 6.26 |
| CHEMBL397990 | — | IC50 | = | 554.0 | nM | 6.26 |
| CHEMBL396535 | — | IC50 | = | 586.0 | nM | 6.23 |
| CHEMBL242510 | — | IC50 | = | 712.0 | nM | 6.15 |
| CHEMBL242937 | — | IC50 | = | 871.0 | nM | 6.06 |
| CHEMBL242511 | — | IC50 | = | 1078.0 | nM | 5.97 |
| CHEMBL429646 | — | IC50 | = | 1231.0 | nM | 5.91 |
| CHEMBL244229 | — | IC50 | = | 1284.0 | nM | 5.89 |
| CHEMBL243823 | — | IC50 | = | 1339.0 | nM | 5.87 |