Assay Detail
Binding
CHEMBL891362
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]deltorphin 2 from delta opioid receptor in rat brain P2 synaptosome
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Transformation of mu-opioid receptor agonists into biologically potent mu-opioid receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.43 | 8.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL412923 | — | — | 1 | 8.25 |
| CHEMBL412924 | — | — | 1 | 7.99 |
| CHEMBL232303 | — | — | 1 | 7.29 |
| CHEMBL396506 | — | — | 1 | 7.11 |
| CHEMBL397177 | — | — | 1 | 6.66 |
| CHEMBL412922 | — | — | 1 | 6.25 |
| CHEMBL397176 | — | — | 1 | 5.85 |
| CHEMBL316446 | ENDOMORPHIN-1 | — | 1 | 5.76 |
| CHEMBL412921 | — | — | 1 | 5.24 |
| CHEMBL333357 | ENDOMORPHIN 2 | — | 1 | 5.22 |
| CHEMBL266988 | — | — | 1 | 5.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL412923 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL412924 | — | Ki | = | 10.3 | nM | 7.99 |
| CHEMBL232303 | — | Ki | = | 51.5 | nM | 7.29 |
| CHEMBL396506 | — | Ki | = | 77.8 | nM | 7.11 |
| CHEMBL397177 | — | Ki | = | 217.0 | nM | 6.66 |
| CHEMBL412922 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL397176 | — | Ki | = | 1416.0 | nM | 5.85 |
| CHEMBL316446 | ENDOMORPHIN-1 | Ki | = | 1750.0 | nM | 5.76 |
| CHEMBL412921 | — | Ki | = | 5755.0 | nM | 5.24 |
| CHEMBL333357 | ENDOMORPHIN 2 | Ki | = | 6080.0 | nM | 5.22 |
| CHEMBL266988 | — | Ki | = | 7358.0 | nM | 5.13 |