Assay Detail
Functional
CHEMBL891741
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Cytotoxicity against mouse P388 cells after 4 days
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and cytotoxic evaluation of C-9 oxidized podophyllotoxin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.87 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 7.92 |
| CHEMBL309880 | PODOPHYLLIC ALDEHYDE | — | 1 | 6.64 |
| CHEMBL79440 | — | — | 1 | 6.60 |
| CHEMBL241925 | — | — | 1 | 5.92 |
| CHEMBL397224 | — | — | 1 | 5.77 |
| CHEMBL244701 | — | — | 1 | 5.72 |
| CHEMBL244515 | — | — | 1 | 5.72 |
| CHEMBL438834 | — | — | 1 | 5.72 |
| CHEMBL397723 | — | — | 1 | 5.70 |
| CHEMBL395081 | — | — | 1 | 5.66 |
| CHEMBL79846 | — | — | 1 | 5.64 |
| CHEMBL244050 | — | — | 1 | 5.29 |
| CHEMBL389784 | — | — | 1 | 5.00 |
| CHEMBL244256 | — | — | 1 | 4.92 |
| CHEMBL242355 | — | — | 1 | - |
| CHEMBL242562 | — | — | 1 | - |
| CHEMBL244052 | — | — | 1 | - |
| CHEMBL243844 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL309880 | PODOPHYLLIC ALDEHYDE | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL79440 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL241925 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL397224 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL244701 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL244515 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL438834 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL397723 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL395081 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL79846 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL244050 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL389784 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL244256 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL242355 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL242562 | — | IC50 | - | — | - | |
| CHEMBL244052 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL243844 | — | IC50 | > | 20000.0 | nM | - |