Assay Detail
Functional
CHEMBL891821
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 LAI with RT F227C mutation in MT4 cells by EGFP based replication assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis of novel diarylpyrimidine analogues of TMC278 and their antiviral activity against HIV-1 wild-type and mutant strains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 8.31 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL242408 | — | — | 1 | 9.52 |
| CHEMBL175691 | RILPIVIRINE | 4.0 | 1 | 9.30 |
| CHEMBL242616 | — | — | 1 | 9.30 |
| CHEMBL231281 | — | — | 1 | 9.15 |
| CHEMBL242617 | — | — | 1 | 9.10 |
| CHEMBL231582 | — | — | 1 | 9.00 |
| CHEMBL242189 | — | — | 1 | 8.96 |
| CHEMBL231482 | — | — | 1 | 8.92 |
| CHEMBL231282 | — | — | 1 | 8.85 |
| CHEMBL242407 | — | — | 1 | 8.41 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 7.33 |
| CHEMBL388225 | — | — | 1 | 7.01 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.08 |
| CHEMBL593 | DELAVIRDINE | 4.0 | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL242408 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL175691 | RILPIVIRINE | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL242616 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL231281 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL242617 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL231582 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL242189 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL231482 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL231282 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL242407 | — | EC50 | = | 3.9 | nM | 8.41 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 46.9 | nM | 7.33 |
| CHEMBL388225 | — | EC50 | = | 98.4 | nM | 7.01 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 827.0 | nM | 6.08 |
| CHEMBL593 | DELAVIRDINE | EC50 | = | 4560.0 | nM | 5.34 |