Assay Detail
Binding
CHEMBL892222
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Displacement of [3H]L-AP4 from rat recombinant mGluR4 expressed in BHK cells by SPA assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | BHK |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Metabotropic glutamate receptor 4 (CHEMBL2787) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans C1'-2'-2-(2'-phosphonocyclopropyl)glycines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.51 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL33567 | — | — | 1 | 6.80 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 5.47 |
| CHEMBL442076 | — | — | 1 | 5.13 |
| CHEMBL392420 | — | — | 1 | 4.62 |
| CHEMBL392419 | — | — | 1 | - |
| CHEMBL234138 | — | — | 1 | - |
| CHEMBL396319 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL33567 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL575060 | GLUTAMIC ACID | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL442076 | — | Ki | = | 7400.0 | nM | 5.13 |
| CHEMBL392420 | — | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL392419 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL234138 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL396319 | — | Ki | = | 630000.0 | nM | - |