Assay Detail
Binding
CHEMBL892232
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]citalopram from human 5HT transporter expressed in HEK293 cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Naphthyl piperazines with dual activity as 5-HT1D antagonists and 5-HT reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.66 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL83617 | — | — | 1 | 10.00 |
| CHEMBL234447 | — | — | 1 | 9.10 |
| CHEMBL3706925 | — | — | 1 | 8.89 |
| CHEMBL3706923 | — | — | 1 | 8.89 |
| CHEMBL391272 | — | — | 1 | 8.68 |
| CHEMBL233210 | — | — | 1 | 8.66 |
| CHEMBL391271 | — | — | 1 | 8.52 |
| CHEMBL391273 | — | — | 1 | 8.24 |
| CHEMBL234448 | — | — | 1 | 8.13 |
| CHEMBL234449 | — | — | 1 | 8.09 |
| CHEMBL3706924 | — | — | 1 | 8.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL83617 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL234447 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL3706925 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL3706923 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL391272 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL233210 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL391271 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL391273 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL234448 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL234449 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL3706924 | — | Ki | = | 8.8 | nM | 8.06 |