Assay Detail
Binding
CHEMBL892377
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Binding affinity to muscarinic M1 receptor
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Quantitative structure-selectivity relationship for M2 selectivity between M1 and M2 of piperidinyl piperidine derivatives as muscarinic antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 7.51 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308566 | — | — | 1 | 8.19 |
| CHEMBL420008 | — | — | 1 | 8.04 |
| CHEMBL72408 | — | — | 1 | 8.01 |
| CHEMBL440491 | — | — | 1 | 7.98 |
| CHEMBL70860 | — | — | 1 | 7.97 |
| CHEMBL72957 | — | — | 1 | 7.83 |
| CHEMBL421113 | — | — | 1 | 7.59 |
| CHEMBL73893 | — | — | 1 | 7.50 |
| CHEMBL422770 | — | — | 1 | 7.48 |
| CHEMBL72494 | — | — | 1 | 7.43 |
| CHEMBL74352 | — | — | 1 | 7.39 |
| CHEMBL72551 | — | — | 1 | 7.38 |
| CHEMBL72363 | — | — | 1 | 7.24 |
| CHEMBL307234 | — | — | 1 | 7.22 |
| CHEMBL305607 | — | — | 1 | 7.22 |
| CHEMBL74117 | — | — | 1 | 7.17 |
| CHEMBL73245 | — | — | 1 | 7.13 |
| CHEMBL72787 | — | — | 1 | 7.02 |
| CHEMBL70848 | — | — | 1 | 6.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308566 | — | Ki | = | 6.486 | nM | 8.19 |
| CHEMBL420008 | — | Ki | = | 9.099 | nM | 8.04 |
| CHEMBL72408 | — | Ki | = | 9.795 | nM | 8.01 |
| CHEMBL440491 | — | Ki | = | 10.5 | nM | 7.98 |
| CHEMBL70860 | — | Ki | = | 10.79 | nM | 7.97 |
| CHEMBL72957 | — | Ki | = | 14.76 | nM | 7.83 |
| CHEMBL421113 | — | Ki | = | 25.82 | nM | 7.59 |
| CHEMBL73893 | — | Ki | = | 31.7 | nM | 7.50 |
| CHEMBL422770 | — | Ki | = | 33.34 | nM | 7.48 |
| CHEMBL72494 | — | Ki | = | 37.41 | nM | 7.43 |
| CHEMBL74352 | — | Ki | = | 40.74 | nM | 7.39 |
| CHEMBL72551 | — | Ki | = | 42.17 | nM | 7.38 |
| CHEMBL72363 | — | Ki | = | 57.02 | nM | 7.24 |
| CHEMBL307234 | — | Ki | = | 60.39 | nM | 7.22 |
| CHEMBL305607 | — | Ki | = | 60.81 | nM | 7.22 |
| CHEMBL74117 | — | Ki | = | 68.08 | nM | 7.17 |
| CHEMBL73245 | — | Ki | = | 74.47 | nM | 7.13 |
| CHEMBL72787 | — | Ki | = | 95.72 | nM | 7.02 |
| CHEMBL70848 | — | Ki | = | 116.68 | nM | 6.93 |