Assay Detail
Binding
CHEMBL892410
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]PIB from beta amyloid in brain homogenate from Alzheimer's patient
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dibenzothiazoles as novel amyloid-imaging agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.66 | 8.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL242130 | — | — | 1 | 8.17 |
| CHEMBL207456 | PITTSBURGH COMPOUND B | 2.0 | 1 | 7.72 |
| CHEMBL242347 | — | — | 1 | 7.68 |
| CHEMBL394523 | — | — | 1 | 7.66 |
| CHEMBL242132 | — | — | 1 | 7.64 |
| CHEMBL398155 | — | — | 1 | 7.60 |
| CHEMBL243630 | — | — | 1 | 7.60 |
| CHEMBL396212 | — | — | 1 | 7.57 |
| CHEMBL243838 | — | — | 1 | 7.47 |
| CHEMBL241917 | — | — | 1 | 7.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL242130 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL207456 | PITTSBURGH COMPOUND B | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL242347 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL394523 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL242132 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL398155 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL243630 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL396212 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL243838 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL241917 | — | Ki | = | 36.0 | nM | 7.44 |