Compound Detail
CHEMBL394523
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Basic Information
| ChEMBL ID | CHEMBL394523 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PSNPHOVUFPQVPA-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
373.5
MW (Da)
6.28
ALogP
5
HBA
1
HBD
37.8
PSA (Ų)
0.40
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 7.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Amyloid-beta precursor protein CHEMBL2487 | Ki | 7.66 | 7.66 | 22.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Amyloid-beta precursor protein | Ki | = | 22.0 | nM | 7.66 | Displacement of [3H]PIB from beta amyloid in brain homogenate from Alzheimer's p... | 17293116 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17293116 | 10.1016/j.bmc.2006.11.022 | Amyloid-beta precursor protein | 1 |
Data from ChEMBL 36 via Core Engine