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Assay Detail

CHEMBL892625

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antagonist activity in rat uterus by uterotonic assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Tissue Uterus
Confidence 9 — Direct single protein target
Curated By Expert

Target

Oxytocin receptor (CHEMBL3996)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Synthesis and biological activity of oxytocin analogues containing conformationally-restricted residues in position 7.
Fragiadaki M, Magafa V, Borovicková L, Slaninová J, Cordopatis P.
Eur J Med Chem (2007) 42 : 799 -806
PubMed 17316912 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 21 7.54 8.31

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL438849 1 8.31
CHEMBL233281 1 8.30
CHEMBL382301 ATOSIBAN 4.0 1 8.29
CHEMBL233328 1 8.20
CHEMBL434193 1 8.07
CHEMBL394266 1 8.06
CHEMBL265630 1 8.00
CHEMBL441128 1 7.93
CHEMBL393020 1 7.90
CHEMBL233080 1 7.87
CHEMBL234377 1 7.80
CHEMBL393021 1 7.75
CHEMBL415418 1 7.45
CHEMBL394267 1 7.40
CHEMBL394411 1 7.36
CHEMBL435159 1 7.00
CHEMBL394268 1 6.91
CHEMBL232501 1 6.45
CHEMBL415417 1 6.13
CHEMBL397407 1 5.60
CHEMBL233133 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL438849 Kd = 4.898 nM 8.31
CHEMBL233281 Kd = 5.012 nM 8.30
CHEMBL382301 ATOSIBAN Kd = 5.129 nM 8.29
CHEMBL233328 Kd = 6.31 nM 8.20
CHEMBL434193 Kd = 8.511 nM 8.07
CHEMBL394266 Kd = 8.71 nM 8.06
CHEMBL265630 Kd = 10.0 nM 8.00
CHEMBL441128 Kd = 11.75 nM 7.93
CHEMBL393020 Kd = 12.59 nM 7.90
CHEMBL233080 Kd = 13.49 nM 7.87
CHEMBL234377 Kd = 15.85 nM 7.80
CHEMBL393021 Kd = 17.78 nM 7.75
CHEMBL415418 Kd = 35.48 nM 7.45
CHEMBL394267 Kd = 39.81 nM 7.40
CHEMBL394411 Kd = 43.65 nM 7.36
CHEMBL435159 Kd = 100.0 nM 7.00
CHEMBL394268 Kd = 123.03 nM 6.91
CHEMBL232501 Kd = 354.81 nM 6.45
CHEMBL415417 Kd = 741.31 nM 6.13
CHEMBL397407 Kd = 2511.89 nM 5.60
CHEMBL233133 Kd = 954992586.02 nM -