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Compound Detail

CHEMBL394267

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CCc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1

Basic Information

ChEMBL ID CHEMBL394267
Phase Preclinical
Structure Type MOL
InChI Key ONPHDFZBCZCBOB-YGTZAJLESA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

992.2
MW (Da)
-1.79
ALogP
13
HBA
11
HBD
362.1
PSA (Ų)
0.07
QED
3
Ro5 Violations
19
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C44H69N11O11S2
MW 992.24
Aromatic Rings 1
Heavy Atoms 68
NP-Likeness 0.44

Activity Summary

Kd 2 meas. best 7.4

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Oxytocin receptor
CHEMBL3996
Kd 7.4 7.4 39.8 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Oxytocin receptor Kd = 39.81 nM 7.4 Antagonist activity in rat uterus by uterotonic assay 17316912

Literature References

PubMed DOI Target Context # Activities
17316912 10.1016/j.ejmech.2006.12.016 Oxytocin receptor 5

Data from ChEMBL 36 via Core Engine