Assay Detail
Functional
CHEMBL892894
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Cytotoxicity against HCT116 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
ABC synthesis and antitumor activity of a series of Annonaceous acetogenin analogs with a threo, trans, threo, trans, threo-bis-tetrahydrofuran core unit.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.38 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL391587 | — | — | 1 | 9.30 |
| CHEMBL234888 | — | — | 1 | 9.22 |
| CHEMBL232977 | — | — | 1 | 8.42 |
| CHEMBL606053 | ASIMICIN | — | 1 | 8.06 |
| CHEMBL443580 | — | — | 1 | 7.80 |
| CHEMBL394665 | — | — | 1 | 7.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL391587 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL234888 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL232977 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL606053 | ASIMICIN | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL443580 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL394665 | — | IC50 | = | 35.0 | nM | 7.46 |