Assay Detail
ADMET
CHEMBL893096
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Cytotoxicity against human THP1 cells
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antileishmanial activity of 6-mono-substituted and 3,6-di-substituted acridines obtained by acylation of proflavine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.37 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL244685 | — | — | 1 | 6.11 |
| CHEMBL397456 | — | — | 1 | 5.96 |
| CHEMBL244123 | — | — | 1 | 5.75 |
| CHEMBL244122 | — | — | 1 | 5.72 |
| CHEMBL244501 | — | — | 1 | 5.68 |
| CHEMBL55400 | PROFLAVINE | 2.0 | 1 | 5.66 |
| CHEMBL244684 | — | — | 1 | 5.60 |
| CHEMBL243903 | — | — | 1 | 5.33 |
| CHEMBL397455 | — | — | 1 | 5.27 |
| CHEMBL244686 | — | — | 1 | 4.87 |
| CHEMBL244120 | — | — | 1 | 4.72 |
| CHEMBL428219 | — | — | 1 | 4.63 |
| CHEMBL244121 | — | — | 1 | 4.57 |
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | - |
| CHEMBL244308 | — | — | 1 | - |
| CHEMBL244683 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL244685 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL397456 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL244123 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL244122 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL244501 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL55400 | PROFLAVINE | IC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL244684 | — | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL243903 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL397455 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL244686 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL244120 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL428219 | — | IC50 | = | 23200.0 | nM | 4.63 |
| CHEMBL244121 | — | IC50 | = | 26800.0 | nM | 4.57 |
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 154500.0 | nM | - |
| CHEMBL244308 | — | IC50 | = | 110300.0 | nM | - |
| CHEMBL244683 | — | IC50 | = | 737500.0 | nM | - |