Assay Detail
Binding
CHEMBL893102
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Displacement of [125I]DOI from 5HT2A receptor in rat cerebral cortex
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel benzodifuran analogs as potent 5-HT2A receptor agonists with ocular hypotensive activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 8.65 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL394325 | — | — | 1 | 9.96 |
| CHEMBL234464 | — | — | 1 | 9.55 |
| CHEMBL232995 | — | — | 1 | 9.54 |
| CHEMBL101008 | — | — | 1 | 9.52 |
| CHEMBL393077 | — | — | 1 | 9.51 |
| CHEMBL234682 | — | — | 1 | 9.42 |
| CHEMBL134519 | — | — | 1 | 9.34 |
| CHEMBL391196 | — | — | 1 | 9.15 |
| CHEMBL394508 | — | — | 1 | 9.07 |
| CHEMBL397321 | — | — | 1 | 9.06 |
| CHEMBL232594 | — | — | 1 | 9.00 |
| CHEMBL394664 | — | — | 1 | 9.00 |
| CHEMBL234837 | — | — | 1 | 8.80 |
| CHEMBL234683 | — | — | 1 | 8.59 |
| CHEMBL232996 | — | — | 1 | 7.85 |
| CHEMBL232997 | — | — | 1 | 6.98 |
| CHEMBL397166 | — | — | 1 | 6.04 |
| CHEMBL234671 | — | — | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL394325 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL234464 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL232995 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL101008 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL393077 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL234682 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL134519 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL391196 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL394508 | — | IC50 | = | 0.86 | nM | 9.07 |
| CHEMBL397321 | — | IC50 | = | 0.88 | nM | 9.06 |
| CHEMBL232594 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL394664 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL234837 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL234683 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL232996 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL232997 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL397166 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL234671 | — | IC50 | = | 4700.0 | nM | 5.33 |