Assay Detail
Binding
CHEMBL893288
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of yeast alpha-D-glucosidase
8
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Saccharomyces cerevisiae |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glucoamylase, intracellular sporulation-specific (CHEMBL1075248) ↗| Type | SINGLE PROTEIN |
| Organism | Saccharomyces cerevisiae S288c |
Publication
Synthesis and evaluation of amino-threoses in D- and L-series: are five membered ring amino-sugars more potent glycosidase inhibitors than the six membered ones?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.17 | 5.70 |
| IC50 | 3 | 7.11 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL389294 | NECTRISINE | — | 1 | 7.40 |
| CHEMBL80254 | — | — | 1 | 6.82 |
| CHEMBL389595 | — | — | 1 | 5.70 |
| CHEMBL120638 | NOJIRIMYCIN | — | 1 | 5.20 |
| CHEMBL395524 | — | — | 1 | 4.60 |
| CHEMBL232457 | — | — | 1 | - |
| CHEMBL396702 | — | — | 1 | - |
| CHEMBL389969 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL389294 | NECTRISINE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL80254 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL389595 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL120638 | NOJIRIMYCIN | Ki | = | 6300.0 | nM | 5.20 |
| CHEMBL395524 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL232457 | — | Ki | = | 830000.0 | nM | - |
| CHEMBL396702 | — | Ki | - | — | - | |
| CHEMBL389969 | — | IC50 | = | 150000.0 | nM | - |