Assay Detail
Binding
CHEMBL893351
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Displacement of [125I]RTI55 from human SERT expressed in COS1 cell membrane
50
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis, inhibition and binding of simple non-nitrogen inhibitors of monoamine transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 50 | 5.54 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL242338 | IODINE 2BETA-CARBOMETHOXY-3BETA-(4 IODOPHENYL)-TROPANE | -1.0 | 1 | 8.22 |
| CHEMBL243141 | — | — | 1 | 6.66 |
| CHEMBL215988 | — | — | 1 | 6.54 |
| CHEMBL388257 | — | — | 1 | 6.36 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.01 |
| CHEMBL397490 | — | — | 2 | 5.73 |
| CHEMBL242920 | — | — | 1 | 5.55 |
| CHEMBL396754 | — | — | 1 | 5.52 |
| CHEMBL243204 | — | — | 1 | 4.57 |
| CHEMBL232879 | — | — | 1 | 4.54 |
| CHEMBL232299 | — | — | 1 | 4.50 |
| CHEMBL388255 | — | — | 1 | 4.33 |
| CHEMBL231684 | — | — | 1 | 4.14 |
| CHEMBL396318 | — | — | 1 | - |
| CHEMBL434959 | — | — | 1 | - |
| CHEMBL232498 | — | — | 1 | - |
| CHEMBL232069 | — | — | 1 | - |
| CHEMBL233532 | — | — | 1 | - |
| CHEMBL394089 | — | — | 1 | - |
| CHEMBL442234 | — | — | 1 | - |
| CHEMBL233530 | — | — | 1 | - |
| CHEMBL393701 | — | — | 1 | - |
| CHEMBL394373 | — | — | 1 | - |
| CHEMBL234379 | — | — | 1 | - |
| CHEMBL232663 | — | — | 1 | - |
| CHEMBL396083 | — | — | 1 | - |
| CHEMBL394585 | — | — | 1 | - |
| CHEMBL245061 | — | — | 1 | - |
| CHEMBL103936 | — | — | 1 | - |
| CHEMBL232671 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL242338 | IODINE 2BETA-CARBOMETHOXY-3BETA-(4 IODOPHENYL)-TROPANE | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL243141 | — | Ki | = | 217.0 | nM | 6.66 |
| CHEMBL215988 | — | Ki | = | 287.0 | nM | 6.54 |
| CHEMBL388257 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL370805 | COCAINE | Ki | = | 965.0 | nM | 6.01 |
| CHEMBL397490 | — | Ki | = | 1850.0 | nM | 5.73 |
| CHEMBL242920 | — | Ki | = | 2810.0 | nM | 5.55 |
| CHEMBL396754 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL397490 | — | Ki | = | 13800.0 | nM | 4.86 |
| CHEMBL243204 | — | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL232879 | — | Ki | = | 28700.0 | nM | 4.54 |
| CHEMBL232299 | — | Ki | = | 32000.0 | nM | 4.50 |
| CHEMBL388255 | — | Ki | = | 46700.0 | nM | 4.33 |
| CHEMBL231684 | — | Ki | = | 73000.0 | nM | 4.14 |
| CHEMBL233088 | — | Ki | = | 149000.0 | nM | - |
| CHEMBL396083 | — | Ki | = | 1460000.0 | nM | - |
| CHEMBL395649 | — | Ki | = | 573000.0 | nM | - |
| CHEMBL438321 | — | Ki | = | 4710000.0 | nM | - |
| CHEMBL234128 | — | Ki | = | 5020000.0 | nM | - |
| CHEMBL234127 | — | Ki | = | 668000.0 | nM | - |
| CHEMBL397520 | — | Ki | = | 4680000.0 | nM | - |
| CHEMBL232070 | — | Ki | = | 2250000.0 | nM | - |
| CHEMBL396082 | — | Ki | = | 417000.0 | nM | - |
| CHEMBL232068 | — | Ki | = | 109000.0 | nM | - |
| CHEMBL231858 | — | Ki | = | 1180000.0 | nM | - |
| CHEMBL232870 | — | Ki | = | 1860000.0 | nM | - |
| CHEMBL395910 | — | Ki | = | 228000.0 | nM | - |
| CHEMBL232675 | — | Ki | = | 1141000.0 | nM | - |
| CHEMBL232674 | — | Ki | = | 1950000.0 | nM | - |
| CHEMBL232867 | — | Ki | = | 296000.0 | nM | - |
| CHEMBL397787 | — | Ki | = | 3388000.0 | nM | - |
| CHEMBL232866 | — | Ki | = | 3800000.0 | nM | - |
| CHEMBL393701 | — | Ki | = | 1910000.0 | nM | - |
| CHEMBL232671 | — | Ki | = | 2240000.0 | nM | - |
| CHEMBL103936 | — | Ki | = | 620000.0 | nM | - |
| CHEMBL245061 | — | Ki | = | 785000.0 | nM | - |
| CHEMBL394585 | — | Ki | = | 2840000.0 | nM | - |
| CHEMBL232672 | — | Ki | = | 2690000.0 | nM | - |
| CHEMBL232663 | — | Ki | = | 1040000.0 | nM | - |
| CHEMBL234379 | — | Ki | = | 1800000.0 | nM | - |
| CHEMBL394373 | — | Ki | = | 185000.0 | nM | - |
| CHEMBL398009 | — | Ki | = | 706000.0 | nM | - |
| CHEMBL233530 | — | Ki | = | 1510000.0 | nM | - |
| CHEMBL442234 | — | Ki | = | 605000.0 | nM | - |
| CHEMBL394089 | — | Ki | = | 9120000.0 | nM | - |
| CHEMBL233532 | — | Ki | = | 390000.0 | nM | - |
| CHEMBL232069 | — | Ki | = | 841000.0 | nM | - |
| CHEMBL232498 | — | Ki | = | 381000.0 | nM | - |
| CHEMBL434959 | — | Ki | = | 532000.0 | nM | - |
| CHEMBL396318 | — | Ki | = | 463000.0 | nM | - |