Assay Detail
Binding
CHEMBL893566
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Inhibition of human recombinant CA5A after 15 mins by CO2 hydration stopped flow assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Carbonic anhydrase 5A, mitochondrial (CHEMBL4789) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Carbonic anhydrase inhibitors. Inhibition of isoforms I, II, IV, VA, VII, IX, and XIV with sulfonamides incorporating fructopyranose-thioureido tails.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.03 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.20 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 7.20 |
| CHEMBL232617 | — | — | 1 | 6.91 |
| CHEMBL233019 | — | — | 1 | 6.15 |
| CHEMBL395981 | — | — | 1 | 6.07 |
| CHEMBL232816 | — | — | 1 | 6.03 |
| CHEMBL395734 | — | — | 1 | 5.98 |
| CHEMBL390035 | — | — | 1 | 4.40 |
| CHEMBL232616 | — | — | 1 | 4.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL232617 | — | Ki | = | 122.0 | nM | 6.91 |
| CHEMBL233019 | — | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL395981 | — | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL232816 | — | Ki | = | 940.0 | nM | 6.03 |
| CHEMBL395734 | — | Ki | = | 1040.0 | nM | 5.98 |
| CHEMBL390035 | — | Ki | = | 39800.0 | nM | 4.40 |
| CHEMBL232616 | — | Ki | = | 43000.0 | nM | 4.37 |