Assay Detail
Binding
CHEMBL893718
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]citalopram from human SERT expressed in HEK293 cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Conformationally restricted homotryptamines 3. Indole tetrahydropyridines and cyclohexenylamines as selective serotonin reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.49 | 9.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL234706 | — | — | 1 | 9.14 |
| CHEMBL396537 | — | — | 1 | 9.00 |
| CHEMBL234705 | — | — | 1 | 8.96 |
| CHEMBL390432 | — | — | 1 | 8.80 |
| CHEMBL231809 | — | — | 1 | 8.51 |
| CHEMBL396540 | — | — | 1 | 8.28 |
| CHEMBL234927 | — | — | 1 | 7.85 |
| CHEMBL234928 | — | — | 1 | 7.72 |
| CHEMBL283899 | — | — | 1 | 7.72 |
| CHEMBL283416 | — | — | 1 | 7.40 |
| CHEMBL394356 | — | — | 1 | 6.82 |
| CHEMBL27025 | — | — | 1 | 6.80 |
| CHEMBL27227 | — | — | 1 | 6.68 |
| CHEMBL283185 | — | — | 1 | 6.62 |
| CHEMBL26655 | — | — | 1 | 6.16 |
| CHEMBL285777 | — | — | 1 | 6.14 |
| CHEMBL234291 | — | — | 1 | 6.11 |
| CHEMBL442534 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL234706 | — | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL396537 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL234705 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL390432 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL231809 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL396540 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL234927 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL234928 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL283899 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL283416 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL394356 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL27025 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL27227 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL283185 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL26655 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL285777 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL234291 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL442534 | — | IC50 | = | 910.0 | nM | 6.04 |