Assay Detail
Binding
CHEMBL893721
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Conformationally restricted homotryptamines 3. Indole tetrahydropyridines and cyclohexenylamines as selective serotonin reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.37 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL390432 | — | — | 1 | 9.47 |
| CHEMBL234706 | — | — | 1 | 9.40 |
| CHEMBL234705 | — | — | 1 | 9.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL390432 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL234706 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL234705 | — | IC50 | = | 0.56 | nM | 9.25 |