Assay Detail
Functional
CHEMBL893773
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at M3 muscarinic receptor in guinea pig assessed as effect on carbachol-induced trachea contraction
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Trachea |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Muscarinic acetylcholine receptor M3 (CHEMBL5498) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Dual M3 antagonists-PDE4 inhibitors. Part 2: Synthesis and SAR of 3-substituted azetidinyl derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 6.95 | 7.90 |
| pA2 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL205654 | — | — | 1 | 7.90 |
| CHEMBL232419 | — | — | 1 | 6.00 |
| CHEMBL396761 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL205654 | — | Kd | = | 12.59 | nM | 7.90 |
| CHEMBL232419 | — | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL396761 | — | pA2 | - | — | - |