Assay Detail
ADMET
CHEMBL893902
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Inhibition of human recombinant CYP3A4
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Radical scavenging and cytochrome P450 3A4 inhibitory activity of bergaptol and geranylcoumarin from grapefruit.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.49 | 4.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL242711 | BERGAPTOL | — | 1 | 4.60 |
| CHEMBL241896 | GERANYLCOUMARIN | — | 1 | 4.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL242711 | BERGAPTOL | IC50 | = | 24920.0 | nM | 4.60 |
| CHEMBL241896 | GERANYLCOUMARIN | IC50 | = | 42930.0 | nM | 4.37 |