Assay Detail
Binding
CHEMBL894442
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Displacement of [3H]T-226296 from rat recombinant MCH1 receptor
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Melanin-concentrating hormone receptor 1 (CHEMBL1075228) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists part 2: A hybrid strategy combining key fragments of HTS hits.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 7.46 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185271 | SNAP-7941 | — | 1 | 9.60 |
| CHEMBL245231 | — | — | 1 | 8.74 |
| CHEMBL242004 | — | — | 1 | 8.66 |
| CHEMBL394569 | — | — | 1 | 8.30 |
| CHEMBL245010 | — | — | 1 | 8.28 |
| CHEMBL389129 | — | — | 1 | 8.09 |
| CHEMBL389128 | — | — | 1 | 8.00 |
| CHEMBL244791 | — | — | 1 | 7.75 |
| CHEMBL244578 | — | — | 1 | 7.64 |
| CHEMBL242003 | — | — | 1 | 7.57 |
| CHEMBL244373 | — | — | 1 | 7.55 |
| CHEMBL244374 | — | — | 1 | 7.51 |
| CHEMBL245229 | — | — | 1 | 7.46 |
| CHEMBL390212 | — | — | 1 | 7.37 |
| CHEMBL244790 | — | — | 1 | 7.19 |
| CHEMBL243794 | — | — | 1 | 7.16 |
| CHEMBL244372 | — | — | 1 | 7.08 |
| CHEMBL244004 | — | — | 1 | 7.00 |
| CHEMBL245008 | — | — | 1 | 6.85 |
| CHEMBL244163 | — | — | 1 | 6.70 |
| CHEMBL395788 | — | — | 1 | 6.46 |
| CHEMBL363548 | CHLOROHALOPERIDOL | — | 1 | 6.46 |
| CHEMBL395789 | — | — | 1 | 6.44 |
| CHEMBL244003 | — | — | 1 | 6.31 |
| CHEMBL244576 | — | — | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185271 | SNAP-7941 | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL245231 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL242004 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL394569 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL245010 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL389129 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL389128 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL244791 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL244578 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL242003 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL244373 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL244374 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL245229 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL390212 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL244790 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL243794 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL244372 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL244004 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL245008 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL244163 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL395788 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL363548 | CHLOROHALOPERIDOL | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL395789 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL244003 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL244576 | — | Ki | = | 540.0 | nM | 6.27 |