Compound Detail
CHEMBL390212
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Basic Information
| ChEMBL ID | CHEMBL390212 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JGHHCQJAWMYFGE-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
458.6
MW (Da)
6.46
ALogP
4
HBA
1
HBD
50.8
PSA (Ų)
0.42
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 7.37
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Melanin-concentrating hormone receptor 1 CHEMBL1075228 | Ki | 7.37 | 7.37 | 43.0 | 1 |
| D(2) dopamine receptor CHEMBL217 | Ki | 6.0 | 6.0 | 1000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Melanin-concentrating hormone receptor 1 | Ki | = | 43.0 | nM | 7.37 | Displacement of [3H]T-226296 from rat recombinant MCH1 receptor | 17668922 |
| D(2) dopamine receptor | Ki | = | 1000.0 | nM | 6.0 | Displacement of [3H]spiperone from human recombinant dopamine D2 receptor | 17668922 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17668922 | 10.1021/jm060383x | Melanin-concentrating hormone receptor 1 | 2 |
| 17668922 | 10.1021/jm060383x | D(2) dopamine receptor | 1 |
Data from ChEMBL 36 via Core Engine