Assay Detail
Functional
CHEMBL894445
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at rat MCH1 receptor expressed in HEK293 cells by FLIPR calcium mobility assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Melanin-concentrating hormone receptor 1 (CHEMBL1075228) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists part 2: A hybrid strategy combining key fragments of HTS hits.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.13 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL394569 | — | — | 1 | 7.14 |
| CHEMBL245231 | — | — | 1 | 6.96 |
| CHEMBL242004 | — | — | 1 | 6.64 |
| CHEMBL389128 | — | — | 1 | 6.50 |
| CHEMBL245010 | — | — | 1 | 6.46 |
| CHEMBL242003 | — | — | 1 | 6.44 |
| CHEMBL243794 | — | — | 1 | 6.24 |
| CHEMBL389129 | — | — | 1 | 6.15 |
| CHEMBL245229 | — | — | 1 | 6.14 |
| CHEMBL244004 | — | — | 1 | 5.89 |
| CHEMBL245008 | — | — | 1 | 5.85 |
| CHEMBL244578 | — | — | 1 | 5.70 |
| CHEMBL395789 | — | — | 1 | 5.62 |
| CHEMBL244791 | — | — | 1 | 5.58 |
| CHEMBL395788 | — | — | 1 | 5.57 |
| CHEMBL244790 | — | — | 1 | 5.27 |
| CHEMBL244003 | — | — | 1 | - |
| CHEMBL244163 | — | — | 1 | - |
| CHEMBL390212 | — | — | 1 | - |
| CHEMBL244576 | — | — | 1 | - |
| CHEMBL244374 | — | — | 1 | - |
| CHEMBL244373 | — | — | 1 | - |
| CHEMBL244372 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL394569 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL245231 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL242004 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL389128 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL245010 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL242003 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL243794 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL389129 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL245229 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL244004 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL245008 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL244578 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL395789 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL244791 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL395788 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL244790 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL244003 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL244163 | — | IC50 | - | — | - | |
| CHEMBL390212 | — | IC50 | - | — | - | |
| CHEMBL244576 | — | IC50 | - | — | - | |
| CHEMBL244374 | — | IC50 | - | — | - | |
| CHEMBL244373 | — | IC50 | - | — | - | |
| CHEMBL244372 | — | IC50 | - | — | - |