Assay Detail
Binding
CHEMBL894558
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Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NIH3T3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
7-Substituted-melatonin and 7-substituted-1-methylmelatonin analogues: effect of substituents on potency and binding affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 7.42 | 9.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45 | MELATONIN | 4.0 | 1 | 9.58 |
| CHEMBL395221 | — | — | 1 | 8.75 |
| CHEMBL231872 | — | — | 1 | 8.57 |
| CHEMBL391350 | — | — | 1 | 8.54 |
| CHEMBL233728 | — | — | 1 | 8.45 |
| CHEMBL233729 | — | — | 1 | 8.38 |
| CHEMBL233308 | — | — | 1 | 8.29 |
| CHEMBL392421 | — | — | 1 | 8.06 |
| CHEMBL233309 | — | — | 1 | 7.98 |
| CHEMBL233310 | — | — | 1 | 7.85 |
| CHEMBL233516 | — | — | 1 | 7.80 |
| CHEMBL392422 | — | — | 1 | 7.71 |
| CHEMBL394406 | — | — | 1 | 7.48 |
| CHEMBL233517 | — | — | 1 | 6.21 |
| CHEMBL394408 | — | — | 1 | 6.02 |
| CHEMBL233740 | — | — | 1 | 5.90 |
| CHEMBL441916 | — | — | 1 | 5.27 |
| CHEMBL233945 | — | — | 1 | 5.23 |
| CHEMBL233311 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45 | MELATONIN | Ki | = | 0.263 | nM | 9.58 |
| CHEMBL395221 | — | Ki | = | 1.778 | nM | 8.75 |
| CHEMBL231872 | — | Ki | = | 2.692 | nM | 8.57 |
| CHEMBL391350 | — | Ki | = | 2.884 | nM | 8.54 |
| CHEMBL233728 | — | Ki | = | 3.548 | nM | 8.45 |
| CHEMBL233729 | — | Ki | = | 4.169 | nM | 8.38 |
| CHEMBL233308 | — | Ki | = | 5.129 | nM | 8.29 |
| CHEMBL392421 | — | Ki | = | 8.71 | nM | 8.06 |
| CHEMBL233309 | — | Ki | = | 10.47 | nM | 7.98 |
| CHEMBL233310 | — | Ki | = | 14.13 | nM | 7.85 |
| CHEMBL233516 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL392422 | — | Ki | = | 19.5 | nM | 7.71 |
| CHEMBL394406 | — | Ki | = | 33.11 | nM | 7.48 |
| CHEMBL233517 | — | Ki | = | 616.6 | nM | 6.21 |
| CHEMBL394408 | — | Ki | = | 954.99 | nM | 6.02 |
| CHEMBL233740 | — | Ki | = | 1258.93 | nM | 5.90 |
| CHEMBL441916 | — | Ki | = | 5370.32 | nM | 5.27 |
| CHEMBL233945 | — | Ki | = | 5888.44 | nM | 5.23 |
| CHEMBL233311 | — | Ki | = | 12882.5 | nM | 4.89 |