Assay Detail
Binding
CHEMBL894559
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Displacement of 2[125I]iodomelatonin from human recombinant MT2 receptor expressed in NIH3T3 cells
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NIH3T3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
7-Substituted-melatonin and 7-substituted-1-methylmelatonin analogues: effect of substituents on potency and binding affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 8.06 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45 | MELATONIN | 4.0 | 1 | 9.47 |
| CHEMBL233308 | — | — | 1 | 9.45 |
| CHEMBL233729 | — | — | 1 | 9.27 |
| CHEMBL391350 | — | — | 1 | 9.17 |
| CHEMBL233728 | — | — | 1 | 9.17 |
| CHEMBL395221 | — | — | 1 | 8.96 |
| CHEMBL233309 | — | — | 1 | 8.88 |
| CHEMBL392422 | — | — | 1 | 8.87 |
| CHEMBL392421 | — | — | 1 | 8.81 |
| CHEMBL231872 | — | — | 1 | 8.76 |
| CHEMBL394406 | — | — | 1 | 8.67 |
| CHEMBL233310 | — | — | 1 | 8.64 |
| CHEMBL233516 | — | — | 1 | 8.58 |
| CHEMBL233740 | — | — | 1 | 6.34 |
| CHEMBL233517 | — | — | 1 | 6.21 |
| CHEMBL233945 | — | — | 1 | 6.17 |
| CHEMBL441916 | — | — | 1 | 6.07 |
| CHEMBL394408 | — | — | 1 | 6.06 |
| CHEMBL233311 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45 | MELATONIN | Ki | = | 0.3388 | nM | 9.47 |
| CHEMBL233308 | — | Ki | = | 0.3548 | nM | 9.45 |
| CHEMBL233729 | — | Ki | = | 0.537 | nM | 9.27 |
| CHEMBL391350 | — | Ki | = | 0.6761 | nM | 9.17 |
| CHEMBL233728 | — | Ki | = | 0.6761 | nM | 9.17 |
| CHEMBL395221 | — | Ki | = | 1.096 | nM | 8.96 |
| CHEMBL233309 | — | Ki | = | 1.318 | nM | 8.88 |
| CHEMBL392422 | — | Ki | = | 1.349 | nM | 8.87 |
| CHEMBL392421 | — | Ki | = | 1.549 | nM | 8.81 |
| CHEMBL231872 | — | Ki | = | 1.738 | nM | 8.76 |
| CHEMBL394406 | — | Ki | = | 2.138 | nM | 8.67 |
| CHEMBL233310 | — | Ki | = | 2.291 | nM | 8.64 |
| CHEMBL233516 | — | Ki | = | 2.63 | nM | 8.58 |
| CHEMBL233740 | — | Ki | = | 457.09 | nM | 6.34 |
| CHEMBL233517 | — | Ki | = | 616.6 | nM | 6.21 |
| CHEMBL233945 | — | Ki | = | 676.08 | nM | 6.17 |
| CHEMBL441916 | — | Ki | = | 851.14 | nM | 6.07 |
| CHEMBL394408 | — | Ki | = | 870.96 | nM | 6.06 |
| CHEMBL233311 | — | Ki | = | 3019.95 | nM | 5.52 |