Assay Detail
Functional
CHEMBL894948
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against TK+ VZV YS in HEL cells assessed as reduction of virus plaque formation after 5 days
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 3 |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antiviral evaluation of 6-(alkyl-heteroaryl)furo[2,3-d]pyrimidin-2(3H)-one nucleosides and analogues with ethynyl, ethenyl, and ethyl spacers at C6 of the furopyrimidine core.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 6.26 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL344738 | CF1743 | — | 1 | 9.00 |
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | 8.00 |
| CHEMBL244824 | — | — | 1 | 7.35 |
| CHEMBL397671 | — | — | 1 | 7.22 |
| CHEMBL144817 | — | — | 1 | 7.18 |
| CHEMBL244826 | — | — | 1 | 7.05 |
| CHEMBL244825 | — | — | 1 | 7.05 |
| CHEMBL244614 | — | — | 1 | 6.44 |
| CHEMBL244615 | — | — | 1 | 6.24 |
| CHEMBL396223 | — | — | 1 | 6.15 |
| CHEMBL243987 | — | — | 1 | 6.14 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 5.85 |
| CHEMBL245043 | — | — | 1 | 5.70 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 5.64 |
| CHEMBL439574 | — | — | 1 | 4.72 |
| CHEMBL388713 | — | — | 1 | 4.57 |
| CHEMBL244194 | — | — | 1 | 4.39 |
| CHEMBL243988 | — | — | 1 | 4.00 |
| CHEMBL244409 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL344738 | CF1743 | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL31634 | BRIVUDINE | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL244824 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL397671 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL144817 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL244826 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL244825 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL244614 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL244615 | — | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL396223 | — | EC50 | = | 710.0 | nM | 6.15 |
| CHEMBL243987 | — | EC50 | = | 720.0 | nM | 6.14 |
| CHEMBL184 | ACYCLOVIR | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL245043 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL182 | GANCICLOVIR | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL439574 | — | EC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL388713 | — | EC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL244194 | — | EC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL243988 | — | EC50 | = | 99000.0 | nM | 4.00 |
| CHEMBL244409 | — | EC50 | >= | 50000.0 | nM | - |