Assay Detail
Functional
CHEMBL894951
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Antiviral activity against thymidine kinase deficient VZV YS/R in HEL cells assessed as reduction of virus plaque formation after 5 days
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 3 |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antiviral evaluation of 6-(alkyl-heteroaryl)furo[2,3-d]pyrimidin-2(3H)-one nucleosides and analogues with ethynyl, ethenyl, and ethyl spacers at C6 of the furopyrimidine core.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 4.45 | 4.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 4.62 |
| CHEMBL243987 | — | — | 1 | 4.58 |
| CHEMBL244824 | — | — | 1 | 4.16 |
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | - |
| CHEMBL396223 | — | — | 1 | - |
| CHEMBL245043 | — | — | 1 | - |
| CHEMBL244826 | — | — | 1 | - |
| CHEMBL244825 | — | — | 1 | - |
| CHEMBL397671 | — | — | 1 | - |
| CHEMBL244614 | — | — | 1 | - |
| CHEMBL244409 | — | — | 1 | - |
| CHEMBL388713 | — | — | 1 | - |
| CHEMBL243988 | — | — | 1 | - |
| CHEMBL144817 | — | — | 1 | - |
| CHEMBL344738 | CF1743 | — | 1 | - |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | - |
| CHEMBL244615 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184 | ACYCLOVIR | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL243987 | — | EC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL244824 | — | EC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL31634 | BRIVUDINE | EC50 | >= | 130000.0 | nM | - |
| CHEMBL396223 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL245043 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL244826 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL244825 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL397671 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL244614 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL244409 | — | EC50 | > | 130000.0 | nM | - |
| CHEMBL388713 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL243988 | — | EC50 | > | 140000.0 | nM | - |
| CHEMBL144817 | — | EC50 | > | 51000.0 | nM | - |
| CHEMBL344738 | CF1743 | EC50 | > | 500.0 | nM | - |
| CHEMBL182 | GANCICLOVIR | EC50 | - | — | - | |
| CHEMBL244615 | — | EC50 | > | 100000.0 | nM | - |