Assay Detail
Functional
CHEMBL895082
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Agonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
11
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Alpha2-adrenoreceptors profile modulation. 3.1 (R)-(+)-m-nitrobiphenyline, a new efficient and alpha2C-subtype selective agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 7.13 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL242693 | — | — | 2 | 8.00 |
| CHEMBL396013 | — | — | 1 | 7.73 |
| CHEMBL374584 | — | — | 1 | 7.33 |
| CHEMBL373535 | — | — | 1 | 7.30 |
| CHEMBL128168 | BIPHENYLINE | — | 1 | 7.24 |
| CHEMBL223836 | — | — | 1 | 7.22 |
| CHEMBL222928 | — | — | 1 | 7.00 |
| CHEMBL242265 | — | — | 1 | 6.95 |
| CHEMBL397753 | — | — | 1 | 6.13 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL242693 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL396013 | — | EC50 | = | 18.62 | nM | 7.73 |
| CHEMBL242693 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL374584 | — | EC50 | = | 46.77 | nM | 7.33 |
| CHEMBL373535 | — | EC50 | = | 50.12 | nM | 7.30 |
| CHEMBL128168 | BIPHENYLINE | EC50 | = | 57.54 | nM | 7.24 |
| CHEMBL223836 | — | EC50 | = | 60.26 | nM | 7.22 |
| CHEMBL222928 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL242265 | — | EC50 | = | 112.2 | nM | 6.95 |
| CHEMBL397753 | — | EC50 | = | 741.31 | nM | 6.13 |
| CHEMBL1437 | NOREPINEPHRINE | EC50 | = | 794.33 | nM | 6.10 |