Assay Detail
Binding
CHEMBL895147
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]CGP-39653 from rat NMDA receptor expressed in BHK cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | BHK |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis, molecular modeling studies, and preliminary pharmacological characterization of all possible 2-(2'-sulfonocyclopropyl)glycine stereoisomers as conformationally constrained L-homocysteic acid analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 5.65 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL282842 | — | — | 1 | 8.05 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 6.70 |
| CHEMBL230951 | — | — | 1 | 5.57 |
| CHEMBL389558 | — | — | 1 | 4.72 |
| CHEMBL389556 | — | — | 1 | 4.66 |
| CHEMBL230950 | — | — | 1 | 4.21 |
| CHEMBL231157 | — | — | 1 | - |
| CHEMBL389557 | — | — | 1 | - |
| CHEMBL230949 | — | — | 1 | - |
| CHEMBL389555 | — | — | 1 | - |
| CHEMBL230852 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL282842 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL575060 | GLUTAMIC ACID | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL230951 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL389558 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL389556 | — | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL230950 | — | Ki | = | 61000.0 | nM | 4.21 |
| CHEMBL231157 | — | Ki | > | 300000.0 | nM | - |
| CHEMBL389557 | — | Ki | > | 300000.0 | nM | - |
| CHEMBL230949 | — | Ki | > | 300000.0 | nM | - |
| CHEMBL389555 | — | Ki | > | 300000.0 | nM | - |
| CHEMBL230852 | — | Ki | = | 150000.0 | nM | - |