Assay Detail
Binding
CHEMBL895627
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]paraxetine from human 5HT transporter expressed in HEK293 cells
12
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Principal component analysis differentiates the receptor binding profiles of three antipsychotic drug candidates from current antipsychotic drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 7 | - | - |
| Ki | 5 | 8.10 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL196514 | — | — | 1 | 9.60 |
| CHEMBL131495 | — | — | 1 | 9.10 |
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 7.50 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 7.20 |
| CHEMBL708 | ZIPRASIDONE | 4.0 | 1 | 7.10 |
| CHEMBL221692 | ADOPRAZINE | 2.0 | 1 | - |
| CHEMBL243712 | AMISULPRIDE | 4.0 | 1 | - |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | - |
| CHEMBL716 | QUETIAPINE | 4.0 | 1 | - |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | - |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | - |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL196514 | — | Ki | = | 0.2512 | nM | 9.60 |
| CHEMBL131495 | — | Ki | = | 0.7943 | nM | 9.10 |
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL71 | CHLORPROMAZINE | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL708 | ZIPRASIDONE | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL221692 | ADOPRAZINE | Activity | - | — | - | |
| CHEMBL243712 | AMISULPRIDE | Activity | - | — | - | |
| CHEMBL85 | RISPERIDONE | Activity | - | — | - | |
| CHEMBL716 | QUETIAPINE | Activity | - | — | - | |
| CHEMBL715 | OLANZAPINE | Activity | - | — | - | |
| CHEMBL42 | CLOZAPINE | Activity | - | — | - | |
| CHEMBL54 | HALOPERIDOL | Activity | - | — | - |