Assay Detail
ADMET
CHEMBL896225
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Inhibition of CYP3A4
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Inhibitors of tumor progression loci-2 (Tpl2) kinase and tumor necrosis factor alpha (TNF-alpha) production: selectivity and in vivo antiinflammatory activity of novel 8-substituted-4-anilino-6-aminoquinoline-3-carbonitriles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.86 | 5.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL436817 | — | — | 1 | 5.05 |
| CHEMBL230761 | — | — | 1 | 4.82 |
| CHEMBL230654 | — | — | 1 | 4.80 |
| CHEMBL395573 | — | — | 1 | 4.75 |
| CHEMBL230232 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL436817 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL230761 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL230654 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL395573 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL230232 | — | IC50 | - | — | - |