Assay Detail
Functional
CHEMBL896493
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Antiviral activity against VZV in human foreskin fibroblast assessed as inhibition of virus plaque formation
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
7-Oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamides: synthesis and biological activity of a new class of highly potent inhibitors of human cytomegalovirus DNA polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.62 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL232115 | — | — | 1 | 9.00 |
| CHEMBL233179 | — | — | 1 | 8.70 |
| CHEMBL232954 | — | — | 1 | 7.70 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 5.09 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL232115 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL233179 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL232954 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL184 | ACYCLOVIR | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL182 | GANCICLOVIR | IC50 | - | — | - |