Assay Detail
Binding
CHEMBL896595
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Displacement of [3H]nemonapride from rat dopamine D2 receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
R-(-)-N-alkyl-11-hydroxy-10-hydroxymethyl- and 10-methyl-aporphines as 5-HT1A receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.32 | 5.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL233566 | — | — | 1 | 5.87 |
| CHEMBL392447 | — | — | 1 | 5.42 |
| CHEMBL233567 | — | — | 1 | 5.22 |
| CHEMBL444368 | — | — | 1 | 5.16 |
| CHEMBL53510 | — | — | 1 | 4.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL233566 | — | Ki | = | 1350.0 | nM | 5.87 |
| CHEMBL392447 | — | Ki | = | 3760.0 | nM | 5.42 |
| CHEMBL233567 | — | Ki | = | 6060.0 | nM | 5.22 |
| CHEMBL444368 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL53510 | — | Ki | = | 11500.0 | nM | 4.94 |