Assay Detail
Functional
CHEMBL896903
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Induction of cholesterol efflux in THP1 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
2-Aryl-N-acyl indole derivatives as liver X receptor (LXR) agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.48 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL59030 | — | — | 1 | 8.00 |
| CHEMBL62136 | T091317 | — | 1 | 7.48 |
| CHEMBL392996 | — | — | 1 | 7.29 |
| CHEMBL233369 | — | — | 1 | 6.17 |
| CHEMBL393966 | — | — | 1 | 5.62 |
| CHEMBL397564 | — | — | 1 | 5.61 |
| CHEMBL397612 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL59030 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL62136 | T091317 | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL392996 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL233369 | — | EC50 | = | 680.0 | nM | 6.17 |
| CHEMBL393966 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL397564 | — | EC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL397612 | — | EC50 | = | 7000.0 | nM | 5.16 |