Assay Detail
Functional
CHEMBL897089
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against Trypanosoma brucei
14
Total Activities
14
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 6.01 | 6.82 |
| IC50 | 1 | 8.34 | 8.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 8.34 |
| CHEMBL233348 | — | — | 1 | 6.82 |
| CHEMBL535173 | — | — | 1 | 6.26 |
| CHEMBL537483 | — | — | 1 | 6.17 |
| CHEMBL233549 | — | — | 1 | 6.09 |
| CHEMBL233339 | — | — | 1 | 6.02 |
| CHEMBL392238 | — | — | 1 | 6.02 |
| CHEMBL234180 | — | — | 1 | 6.01 |
| CHEMBL536752 | — | — | 1 | 6.00 |
| CHEMBL233347 | — | — | 1 | 6.00 |
| CHEMBL231735 | — | — | 1 | 5.78 |
| CHEMBL538585 | — | — | 1 | 5.52 |
| CHEMBL395223 | — | — | 1 | 5.48 |
| CHEMBL55756 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL233348 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL535173 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL537483 | — | EC50 | = | 680.0 | nM | 6.17 |
| CHEMBL233549 | — | EC50 | = | 820.0 | nM | 6.09 |
| CHEMBL233339 | — | EC50 | = | 960.0 | nM | 6.02 |
| CHEMBL392238 | — | EC50 | = | 950.0 | nM | 6.02 |
| CHEMBL234180 | — | EC50 | = | 980.0 | nM | 6.01 |
| CHEMBL536752 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL233347 | — | EC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL231735 | — | EC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL538585 | — | EC50 | = | 3010.0 | nM | 5.52 |
| CHEMBL395223 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL55756 | — | EC50 | > | 50000.0 | nM | - |