Assay Detail
Functional
CHEMBL897527
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Antiproliferative activity against human DU145 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel potent antimitotic heterocyclic ketones: synthesis, antiproliferative activity, and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.26 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.03 |
| CHEMBL230741 | — | — | 1 | 7.58 |
| CHEMBL238333 | — | — | 1 | 7.47 |
| CHEMBL237263 | — | — | 1 | 7.41 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 7.28 |
| CHEMBL391405 | — | — | 1 | 7.12 |
| CHEMBL237475 | — | — | 1 | 6.99 |
| CHEMBL236835 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL230741 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL238333 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL237263 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL61 | PODOFILOX | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL391405 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL237475 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL236835 | — | IC50 | = | 603.0 | nM | 6.22 |