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Assay Detail

CHEMBL897706

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Binding
Inhibition of CETP
ChEMBL ↗
102
Total Activities
85
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cholesteryl ester transfer protein (CHEMBL3572) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

2D Quantitative structure-activity relationship studies on a series of cholesteryl ester transfer protein inhibitors.
Castilho MS, Guido RV, Andricopulo AD.
Bioorg Med Chem (2007) 15 : 6242 -6252
PubMed 17604633 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 102 6.05 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL69699 — — 1 7.70
CHEMBL237396 — — 1 7.52
CHEMBL69563 — — 1 7.52
CHEMBL67055 — — 2 7.22
CHEMBL237627 — — 1 7.22
CHEMBL235525 — — 2 7.16
CHEMBL419437 — — 1 7.10
CHEMBL302306 — — 1 7.10
CHEMBL69885 — — 1 7.10
CHEMBL71379 — — 1 7.10
CHEMBL235507 — — 2 7.10
CHEMBL308423 — — 1 7.05
CHEMBL66503 — — 1 7.05
CHEMBL237163 — — 2 7.05
CHEMBL305995 — — 1 7.00
CHEMBL303472 — — 2 7.00
CHEMBL68688 — — 1 7.00
CHEMBL68856 — — 1 7.00
CHEMBL302786 — — 1 7.00
CHEMBL297971 — — 1 6.85
CHEMBL305003 — — 2 6.70
CHEMBL237397 — — 1 6.70
CHEMBL305278 — — 1 6.70
CHEMBL69971 — — 1 6.70
CHEMBL67395 — — 1 6.70
CHEMBL66703 — — 1 6.70
CHEMBL303937 — — 1 6.70
CHEMBL68632 — — 1 6.70
CHEMBL68805 — — 1 6.52
CHEMBL68726 — — 2 6.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL69699 — IC50 = 20.0 nM 7.70
CHEMBL237396 — IC50 = 30.0 nM 7.52
CHEMBL69563 — IC50 = 30.0 nM 7.52
CHEMBL67055 — IC50 = 60.0 nM 7.22
CHEMBL67055 — IC50 = 60.26 nM 7.22
CHEMBL237627 — IC50 = 60.0 nM 7.22
CHEMBL235525 — IC50 = 70.0 nM 7.16
CHEMBL235525 — IC50 = 70.79 nM 7.15
CHEMBL235507 — IC50 = 80.0 nM 7.10
CHEMBL235507 — IC50 = 79.43 nM 7.10
CHEMBL71379 — IC50 = 80.0 nM 7.10
CHEMBL419437 — IC50 = 80.0 nM 7.10
CHEMBL69885 — IC50 = 80.0 nM 7.10
CHEMBL302306 — IC50 = 80.0 nM 7.10
CHEMBL237163 — IC50 = 90.0 nM 7.05
CHEMBL66503 — IC50 = 90.0 nM 7.05
CHEMBL308423 — IC50 = 90.0 nM 7.05
CHEMBL237163 — IC50 = 89.13 nM 7.05
CHEMBL303472 — IC50 = 100.0 nM 7.00
CHEMBL303472 — IC50 = 100.0 nM 7.00
CHEMBL68856 — IC50 = 100.0 nM 7.00
CHEMBL302786 — IC50 = 100.0 nM 7.00
CHEMBL305995 — IC50 = 100.0 nM 7.00
CHEMBL68688 — IC50 = 100.0 nM 7.00
CHEMBL297971 — IC50 = 140.0 nM 6.85
CHEMBL305003 — IC50 = 199.53 nM 6.70
CHEMBL69971 — IC50 = 200.0 nM 6.70
CHEMBL68632 — IC50 = 200.0 nM 6.70
CHEMBL303937 — IC50 = 200.0 nM 6.70
CHEMBL67395 — IC50 = 200.0 nM 6.70
CHEMBL237397 — IC50 = 200.0 nM 6.70
CHEMBL305003 — IC50 = 200.0 nM 6.70
CHEMBL66703 — IC50 = 200.0 nM 6.70
CHEMBL305278 — IC50 = 200.0 nM 6.70
CHEMBL67709 — IC50 = 300.0 nM 6.52
CHEMBL419999 — IC50 = 300.0 nM 6.52
CHEMBL68805 — IC50 = 300.0 nM 6.52
CHEMBL125629 — IC50 = 300.0 nM 6.52
CHEMBL68726 — IC50 = 302.0 nM 6.52
CHEMBL68726 — IC50 = 300.0 nM 6.52
CHEMBL431556 — IC50 = 300.0 nM 6.52
CHEMBL67512 — IC50 = 400.0 nM 6.40
CHEMBL303833 — IC50 = 400.0 nM 6.40
CHEMBL69187 — IC50 = 398.11 nM 6.40
CHEMBL431366 — IC50 = 400.0 nM 6.40
CHEMBL69187 — IC50 = 400.0 nM 6.40
CHEMBL338700 — IC50 = 420.0 nM 6.38
CHEMBL288060 — IC50 = 480.0 nM 6.32
CHEMBL68918 — IC50 = 500.0 nM 6.30
CHEMBL419781 — IC50 = 660.0 nM 6.18