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Compound Detail

CHEMBL288060

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OC(CN(Cc1cccc(-c2ccco2)c1)c1cccc(Oc2ccccc2)c1)C(F)(F)F

Basic Information

ChEMBL ID CHEMBL288060
Phase Preclinical
Structure Type MOL
InChI Key IUHOHDJSCNYKAW-UHFFFAOYSA-N
2
Targets
5
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

453.5
MW (Da)
6.67
ALogP
4
HBA
1
HBD
45.8
PSA (Ų)
0.32
QED
1
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H22F3NO3
MW 453.46
Aromatic Rings 4
Heavy Atoms 33
NP-Likeness -0.94

Activity Summary

IC50 5 meas. best 6.32

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Cholesteryl ester transfer protein
CHEMBL1163116
IC50 6.32 6.32 480.0 1
Cholesteryl ester transfer protein
CHEMBL3572
IC50 6.32 5.81 480.0 4

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
11425523 10.1016/s0960-894x(01)00244-x Cholesteryl ester transfer protein 2
17604633 10.1016/j.bmc.2007.06.021 Cholesteryl ester transfer protein 1
20116902 10.1016/j.ejmech.2009.12.070 Cholesteryl ester transfer protein 1
26200936 10.1021/acs.jmedchem.5b00258 Cholesteryl ester transfer protein 1

Data from ChEMBL 36 via Core Engine