Assay Detail
Binding
CHEMBL897883
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Inhibition of human factor 10a
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Enantiopure five-membered cyclicdiamine derivatives as potent and selective inhibitors of factor Xa. Improving in vitro metabolic stability via core modifications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 43 | 8.66 | 9.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL236228 | — | — | 1 | 9.68 |
| CHEMBL400017 | — | — | 1 | 9.57 |
| CHEMBL235367 | — | — | 1 | 9.44 |
| CHEMBL399418 | — | — | 1 | 9.41 |
| CHEMBL233992 | — | — | 1 | 9.37 |
| CHEMBL235593 | — | — | 1 | 9.36 |
| CHEMBL437555 | — | — | 1 | 9.30 |
| CHEMBL237064 | — | — | 1 | 9.28 |
| CHEMBL236021 | — | — | 1 | 9.25 |
| CHEMBL237065 | — | — | 1 | 9.25 |
| CHEMBL394129 | — | — | 1 | 9.24 |
| CHEMBL392297 | — | — | 1 | 9.19 |
| CHEMBL236227 | — | — | 1 | 9.15 |
| CHEMBL393533 | — | — | 1 | 9.13 |
| CHEMBL398776 | — | — | 1 | 9.08 |
| CHEMBL235369 | — | — | 1 | 9.03 |
| CHEMBL236643 | — | — | 1 | 9.00 |
| CHEMBL392508 | — | — | 1 | 8.96 |
| CHEMBL391635 | — | — | 1 | 8.89 |
| CHEMBL401444 | — | — | 1 | 8.80 |
| CHEMBL538905 | — | — | 1 | 8.80 |
| CHEMBL442079 | — | — | 1 | 8.77 |
| CHEMBL235594 | — | — | 1 | 8.77 |
| CHEMBL238356 | — | — | 1 | 8.77 |
| CHEMBL401235 | — | — | 1 | 8.72 |
| CHEMBL238354 | — | — | 1 | 8.70 |
| CHEMBL237286 | — | — | 1 | 8.68 |
| CHEMBL235148 | — | — | 1 | 8.68 |
| CHEMBL235150 | — | — | 1 | 8.66 |
| CHEMBL237707 | — | — | 1 | 8.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL236228 | — | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL400017 | — | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL235367 | — | Ki | = | 0.36 | nM | 9.44 |
| CHEMBL399418 | — | Ki | = | 0.39 | nM | 9.41 |
| CHEMBL233992 | — | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL235593 | — | Ki | = | 0.44 | nM | 9.36 |
| CHEMBL437555 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL237064 | — | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL236021 | — | Ki | = | 0.56 | nM | 9.25 |
| CHEMBL237065 | — | Ki | = | 0.56 | nM | 9.25 |
| CHEMBL394129 | — | Ki | = | 0.58 | nM | 9.24 |
| CHEMBL392297 | — | Ki | = | 0.64 | nM | 9.19 |
| CHEMBL236227 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL393533 | — | Ki | = | 0.74 | nM | 9.13 |
| CHEMBL398776 | — | Ki | = | 0.84 | nM | 9.08 |
| CHEMBL235369 | — | Ki | = | 0.93 | nM | 9.03 |
| CHEMBL236643 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL392508 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL391635 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL401444 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL538905 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL442079 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL238356 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL235594 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL401235 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL238354 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL237286 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL235148 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL235150 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL237707 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL237705 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL238148 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL445941 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL430367 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL237924 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL392005 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL400016 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL237922 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL237923 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL236440 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL392006 | — | Ki | = | 163.0 | nM | 6.79 |
| CHEMBL236439 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL236642 | — | Ki | = | 10870.0 | nM | 4.96 |