Compound Detail
CHEMBL401235
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O=C(N[C@H]1C[C@H](C(=O)O)C[C@H]1NC(=O)c1ccc(Cl)s1)c1ccc(-n2ccccc2=O)cc1
Basic Information
| ChEMBL ID | CHEMBL401235 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YCMDRFHFKJJFQF-BHYGNILZSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
12
Publications
0
Known Names
Molecular Properties
485.9
MW (Da)
2.94
ALogP
6
HBA
3
HBD
117.5
PSA (Ų)
0.50
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 8.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Coagulation factor X CHEMBL244 | Ki | 8.72 | 8.72 | 1.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Coagulation factor X | Ki | = | 1.9 | nM | 8.72 | Inhibition of human factor 10a | 17643988 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17643988 | 10.1016/j.bmcl.2007.07.020 | Coagulation factor X | 1 |
| 17643988 | 10.1016/j.bmcl.2007.07.020 | Plasma | 1 |
| 17643988 | 10.1016/j.bmcl.2007.07.020 | Coagulation factor VII | 1 |
| 17643988 | 10.1016/j.bmcl.2007.07.020 | Unchecked | 1 |
| 17643988 | 10.1016/j.bmcl.2007.07.020 | Plasma kallikrein | 1 |
| 17643988 | 10.1016/j.bmcl.2007.07.020 | Trypsin | 1 |
| 17643988 | 10.1016/j.bmcl.2007.07.020 | Vitamin K-dependent protein C | 1 |
| 17643988 | 10.1016/j.bmcl.2007.07.020 | Plasminogen | 1 |
| 17643988 | 10.1016/j.bmcl.2007.07.020 | Tissue-type plasminogen activator | 1 |
| 17643988 | 10.1016/j.bmcl.2007.07.020 | Urokinase-type plasminogen activator | 1 |
| 17643988 | 10.1016/j.bmcl.2007.07.020 | Coagulation factor XI | 1 |
| 17643988 | 10.1016/j.bmcl.2007.07.020 | Prothrombin | 1 |
Data from ChEMBL 36 via Core Engine