Assay Detail
Binding
CHEMBL897887
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Inhibition of human factor 11a
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Enantiopure five-membered cyclicdiamine derivatives as potent and selective inhibitors of factor Xa. Improving in vitro metabolic stability via core modifications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.10 | 5.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL392297 | — | — | 1 | 5.17 |
| CHEMBL437555 | — | — | 1 | 5.13 |
| CHEMBL394129 | — | — | 1 | 4.99 |
| CHEMBL237065 | — | — | 1 | - |
| CHEMBL401235 | — | — | 1 | - |
| CHEMBL237705 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL392297 | — | Ki | = | 6680.0 | nM | 5.17 |
| CHEMBL437555 | — | Ki | = | 7380.0 | nM | 5.13 |
| CHEMBL394129 | — | Ki | = | 10170.0 | nM | 4.99 |
| CHEMBL237065 | — | Ki | - | — | - | |
| CHEMBL401235 | — | Ki | > | 11000.0 | nM | - |
| CHEMBL237705 | — | Ki | > | 11000.0 | nM | - |