Assay Detail
Binding
CHEMBL897892
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human thrombin
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Enantiopure five-membered cyclicdiamine derivatives as potent and selective inhibitors of factor Xa. Improving in vitro metabolic stability via core modifications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.35 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL392297 | — | — | 1 | 5.40 |
| CHEMBL437555 | — | — | 1 | 5.40 |
| CHEMBL394129 | — | — | 1 | 5.26 |
| CHEMBL237065 | — | — | 1 | - |
| CHEMBL401235 | — | — | 1 | - |
| CHEMBL237705 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL392297 | — | Ki | = | 3950.0 | nM | 5.40 |
| CHEMBL437555 | — | Ki | = | 4020.0 | nM | 5.40 |
| CHEMBL394129 | — | Ki | = | 5440.0 | nM | 5.26 |
| CHEMBL237065 | — | Ki | - | — | - | |
| CHEMBL401235 | — | Ki | > | 12000.0 | nM | - |
| CHEMBL237705 | — | Ki | > | 12000.0 | nM | - |