Assay Detail
Functional
CHEMBL898137
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Antiproliferative activity against human NB4 cells after 72 hrs
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NB-4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.96 | 7.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL442016 | ADAROTENE | — | 1 | 7.09 |
| CHEMBL236672 | — | — | 1 | 6.96 |
| CHEMBL238378 | — | — | 1 | 6.75 |
| CHEMBL429990 | — | — | 1 | 6.72 |
| CHEMBL238173 | — | — | 1 | 6.58 |
| CHEMBL238172 | — | — | 1 | 6.57 |
| CHEMBL392719 | — | — | 1 | 6.26 |
| CHEMBL428902 | — | — | 1 | 6.00 |
| CHEMBL236657 | — | — | 1 | 5.96 |
| CHEMBL372221 | — | — | 1 | 5.92 |
| CHEMBL235172 | — | — | 1 | 5.79 |
| CHEMBL238379 | — | — | 1 | 5.72 |
| CHEMBL236673 | — | — | 1 | 5.70 |
| CHEMBL393996 | — | — | 1 | 4.75 |
| CHEMBL393995 | — | — | 1 | 4.39 |
| CHEMBL236884 | — | — | 1 | 4.14 |
| CHEMBL238372 | — | — | 1 | - |
| CHEMBL236240 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL442016 | ADAROTENE | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL236672 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL238378 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL429990 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL238173 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL238172 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL392719 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL428902 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL236657 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL372221 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL235172 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL238379 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL236673 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL393996 | — | IC50 | = | 17900.0 | nM | 4.75 |
| CHEMBL393995 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL236884 | — | IC50 | = | 72300.0 | nM | 4.14 |
| CHEMBL238372 | — | IC50 | - | — | - | |
| CHEMBL236240 | — | IC50 | - | — | - |